GLP-1 Dosing Should Be Personalized for Each Patient

The right GLP-1 dose has to be measured and personalised. Most people on one are on a dose chosen for somebody else. The standard protocol starts everyone at the same dose and roughly doubles it every four weeks. A lean man who trains five days a week and someone with a lot of weight to lose get the same pen on the same schedule. A lot of what gets sold as "microdosing" is the same thing with a new label: the standard starting dose, doubled on the same timetable. Microdosing worth the name starts at a fifth to a tenth of that. With these drugs there is not much room between enough and too much. The goal should be appetite control, where the food noise goes quiet and you still enjoy eating. Push past that into suppression and people stop eating properly and lose muscle with the fat. Most of medicine is still one size fits all, and GLP-1s are the clearest example right now. The fix is to measure before the first dose and keep measuring: fasting insulin, HbA1c, CRP, lipids, thyroid, sex hormones, body composition. Labs can move before the weight does. That is what I'm building at Expand Health AI, a plan for one specific person instead of the average. If you're on a GLP-1, did anyone check your baseline before the first injection?